Primary sclerosing neuroendocrine carcinomas of the lung: A clinicopathologic and immunohistochemical study of 10 cases. Am J Clin Pathol 2010 Apr;133(4):618-22
Date
03/17/2010Pubmed ID
20231615DOI
10.1309/AJCPIRV02WXSLHZKScopus ID
2-s2.0-77950467427 (requires institutional sign-in at Scopus site) 7 CitationsAbstract
We describe 10 cases of primary well-differentiated neuroendocrine carcinomas (carcinoid tumor) of the lung with extensive sclerotic changes. The patients were 6 women and 4 men from 20 to 69 years of age. Clinically, patients had symptoms of bronchial obstruction such as cough, dyspnea, and chest pain. Surgical resection of the tumors was accomplished in all the cases. Histologically, all tumors corresponded to the well-differentiated type; however, in 4 cases, lymph node metastases were present. Immunohistochemically, all tumors showed positive staining for neuroendocrine markers, including chromogranin, synaptophysin, CD56, and broad-spectrum keratin. Follow-up information showed that 8 patients were alive after a period ranging from 1 to 5 years. The cases presented highlight an important feature of neuroendocrine carcinomas of the lung not previously addressed, one that may pose a problem not only in the diagnosis but also in the grading of these neoplasms.
Author List
Kalhor N, Suster S, Moran CAMESH terms used to index this publication - Major topics in bold
AdultAged
Biomarkers, Tumor
CD56 Antigen
Carcinoma, Neuroendocrine
Chromogranin A
Female
Follow-Up Studies
Humans
Immunohistochemistry
Keratins
Lung
Lung Neoplasms
Lymphatic Metastasis
Male
Middle Aged
Sclerosis
Synaptophysin
Treatment Outcome