Faculty Collaboration Database

In Nonobese Girls, Waist Circumference as a Predictor of Insulin Resistance Is Comparable to MRI Fat Measures and Superior to BMI. Horm Res Paediatr 2015;84(4):258-65

Date

09/10/2015

Pubmed ID

26352642

Pubmed Central ID

PMC4644098

DOI

10.1159/000439130

Scopus ID

2-s2.0-84947487193 (requires institutional sign-in at Scopus site)   13 Citations

Abstract

OBJECTIVE: The aim of this study was to investigate the degree to which waist circumference (WC), body mass index (BMI), and magnetic resonance imaging (MRI)-measured abdominal fat deposition predict insulin resistance (IR) in nonobese girls of diverse racial and ethnic backgrounds.

METHODS: Fifty-seven nonobese girls (12 African-American, 16 Hispanic White, and 29 non-Hispanic White girls) aged 11-14 years were assessed for WC, MRI hepatic proton density fat fraction, visceral and subcutaneous adipose tissue volume, BMI Z-score, fasting insulin, homeostasis model of assessment (HOMA)-IR, adiponectin, leptin, sex hormone-binding globulin, high-density lipoprotein cholesterol, and triglycerides.

RESULTS: Univariate and multivariate analyses adjusted for race and ethnicity indicated that only WC and visceral adipose tissue volume were independent predictors of fasting insulin and HOMA-IR, while hepatic proton density fat fraction, BMI Z-score, and subcutaneous adipose tissue volume were dependent predictors. Hispanic White girls showed significantly higher mean fasting insulin and HOMA-IR and lower sex hormone-binding globulin than non-Hispanic White girls (p < 0.01).

CONCLUSIONS: In nonobese girls of diverse racial and ethnic backgrounds, WC, particularly when adjusted for race or ethnicity, is an independent predictor of IR comparable to MRI-derived measurements of fat and superior to the BMI Z-score.

Author List

Wolfgram PM, Connor EL, Rehm JL, Eickhoff JC, Zha W, Reeder SB, Allen DB

Author

Peter M. Wolfgram MD Associate Professor in the Pediatrics department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Adiponectin
Adipose Tissue
Adolescent
Blood Glucose
Body Mass Index
Child
Female
Humans
Insulin
Insulin Resistance
Leptin
Magnetic Resonance Imaging
Sex Hormone-Binding Globulin
Triglycerides
Waist Circumference