Evaluation of phospholipid and liposomal S-adenosyl methionine for the treatment of liver injury in a murine model. J Pharm Sci 2010 Apr;99(4):1800-9
Date
09/26/2009Pubmed ID
19780135DOI
10.1002/jps.21950Scopus ID
2-s2.0-77949862007 (requires institutional sign-in at Scopus site) 3 CitationsAbstract
We have used a murine model of Acetaminophen induced hepatoxicity to determine if S-adenosyl methionine 1,4 butanedisulfonate (SD4) in liposomes can prevent liver injury when administered immediately prior to acetaminophen, as judged by serum aspartate aminotransferase and alanine aminotransferase levels, and histological evidence of liver necrosis. No protection was observed when mice received 1 g/kg unencapsulated SD4. Partial protection was observed with 5 or 0.5 mg/kg SD4 in unextruded distearoylphosphatidylglycerol (DSPG) liposomes. Protection comparable to that seen in mice receiving encapsulated SD4 is achieved when mice received lipid alone in equivalent amounts, suggesting that the contribution of encapsulated SD4 to the efficacy of the liposomes may be minimal. Unextruded distearoylphosphatidylcholine (DSPC) liposomes show only slight effects even at 50 mg/kg SD4. This is likely caused by the size of unextruded DSPC lipsomes, because extruded DSPC liposomes, whose size is smaller, are of comparable efficacy to unextruded DSPG liposomes.
Author List
Wagner EJ, Brown CS, Mather JR, Scholcoff C, Krugner-Higby L, Heath TDAuthor
Cecilia Scholcoff MD Associate Professor in the Medicine department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AnimalsChemical and Drug Induced Liver Injury
Liposomes
Liver
Male
Mice
Mice, Inbred C57BL
Phosphatidylglycerols
S-Adenosylmethionine
