Plasma cell-rich thymoma. Am J Clin Pathol 1994 Aug;102(2):199-201
Date
08/01/1994Pubmed ID
8042589DOI
10.1093/ajcp/102.2.199Scopus ID
2-s2.0-0028035290 (requires institutional sign-in at Scopus site) 19 CitationsAbstract
A thymoma in the anterior mediastinum of a 49-year-old woman was histologically remarkable for the presence of a prominent plasma cell stromal component surrounding the neoplastic epithelial elements. Polyclonal immunoreactivity for kappa and lambda light chains was obtained by immunocytochemical staining of the plasma cells in the stroma. Although no evidence of myasthenia gravis or other type of autoimmune process could be demonstrated at the time of initial diagnosis, a polyclonal hypergammaglobulinemia of unknown cause subsequently developed in the patient. This case may represent an extreme example of aberrant immunologic modulation of the thymus to an autoimmune process with massive hyperplasia of the B-cell compartment of the gland.
Author List
Moran CA, Suster S, Koss MNMESH terms used to index this publication - Major topics in bold
FemaleHumans
Immunohistochemistry
Mediastinal Neoplasms
Middle Aged
Plasma Cells
Thymoma
