Pulmonary adenofibroma: report of two cases of an unusual type of hamartomatous lesion of the lung. Histopathology 1993 Dec;23(6):547-51
Date
12/01/1993Pubmed ID
8314238DOI
10.1111/j.1365-2559.1993.tb01241.xScopus ID
2-s2.0-0027730005 (requires institutional sign-in at Scopus site) 33 CitationsAbstract
We report two cases of a primary lung tumour characterized by complex gland-like spaces lined by simple cuboidal to columnar epithelium surrounded by a hyalinized spindle-cell fibroblastic proliferation reminiscent of adenofibromas of the female genital tract. The lesions occurred in a 54-year-old woman and a 56-year-old man. The tumours presented clinically as 1-2 cm, solitary 'coin' lesions and were discovered incidentally on routine chest X-rays. Both lesions were treated by lobectomy. One patient is alive and well with no evidence of disease after 8 years; the other died of myocardial infarction 5 years following resection of his tumour without evidence of recurrence. We interpret these lesions as benign hamartomatous growths; their main importance lies in distinguishing them histologically from other types of pulmonary hamartomas, pulmonary blastomas, intrapulmonary solitary fibrous tumours, and metastases from soft tissue and visceral sarcomas.
Author List
Suster S, Moran CAMESH terms used to index this publication - Major topics in bold
AdenofibromaFemale
Hamartoma
Humans
Immunohistochemistry
Lung Neoplasms
Male
Middle Aged