Medical College of Wisconsin
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Multiple sclerosis: clinical presentation, diagnosis and treatment. Am Fam Physician 1996 Sep 15;54(4):1301-6, 1309-11

Date

09/15/1996

Pubmed ID

8816574

Scopus ID

2-s2.0-0029830737   11 Citations

Abstract

Multiple sclerosis is a chronic inflammatory disease of the central nervous system and is associated with periods of disability (relapse) alternating with periods of recovery (remission) and often results in progressive neurologic disability. Scientists believe that multiple sclerosis may be a T cell-mediated autoimmune disease. Treatment with high-dose pulses of intravenous methyl-prednisolone is usually associated with a good outcome in the short term. A recent study suggests that interferon beta-1b may decrease the number of relapses in relapsing-remitting multiple sclerosis by 30 percent and also may decrease the development of new central nervous system lesions. Recently, another clinical trial of interferon beta-1a showed a 31 percent reduction in relapse rate and a significant reduction in the average number of active lesions. A third trial showed that 20 mg of copolymer-1, a random polymer of glutamic acid, lysine, alanine and tyrosine, reduced relapses by 21 percent without significant side effects. Further investigation is needed, but these new treatments show great promise in alleviating this difficult clinical problem.

Author List

Brod SA, Lindsey JW, Wolinsky JS

Author

Staley A. Brod MD Professor in the Neurology department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Adrenal Cortex Hormones
Central Nervous System
Diagnosis, Differential
Humans
Immunosuppressive Agents
Interferons
Multiple Sclerosis