Oral administration of human or murine interferon alpha suppresses relapses and modifies adoptive transfer in experimental autoimmune encephalomyelitis. J Neuroimmunol 1995 Apr;58(1):61-9
Date
04/01/1995Pubmed ID
7537281DOI
10.1016/0165-5728(94)00188-tScopus ID
2-s2.0-0028903315 (requires institutional sign-in at Scopus site) 43 CitationsAbstract
Chronic relapsing experimental autoimmune encephalitis (CR-EAE) is an inflammatory process of the central nervous system (CNS) that closely resembles the human disease multiple sclerosis (MS). EAE was induced in SJL/J mice and following recovery from the initial attack, animals were fed varying doses of human or murine interferon alpha (IFN-alpha), or mock IFN three times per week. After relapse, concanavalin A-activated spleen cells were transferred adoptively from orally fed animals into recipient animals. Oral administration of human or murine IFN-alpha suppressed relapse in actively immunized animals, modified adoptive transfer of EAE, and decreased mitogen/antigen proliferation and IFN-gamma secretion in both donors and recipients. IFN-alpha acts orally by modifying the encephalitogenicity of donor spleen T cells.
Author List
Brod SA, Khan M, Kerman RH, Pappolla MMESH terms used to index this publication - Major topics in bold
Administration, OralAnimals
Encephalomyelitis, Autoimmune, Experimental
Female
Humans
Immunotherapy, Adoptive
Interferon Type I
Interferon-alpha
Lymph Nodes
Lymphocyte Activation
Mice
Mice, Inbred Strains
Myelin Basic Protein
Recombinant Proteins
Spinal Cord
Spleen
T-Lymphocytes
Time Factors
