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Homeostasis of IL-15 dependent lymphocyte subsets in the liver. Cytokine 2016 06;82:95-101

Date

01/19/2016

Pubmed ID

26778709

Pubmed Central ID

PMC5293139

DOI

10.1016/j.cyto.2015.12.012

Scopus ID

2-s2.0-84952911477   9 Citations

Abstract

IL-15 is a member of the gamma chain family of cytokines (I?c - CD132). The IL-15 receptor (IL-15R) complex consists of 3 subunits: the ligand-binding IL-15RI? chain (CD215), the I? chain (CD122; also used by IL-2), and the common I? chain. The biological activities of IL-15 are mostly mediated by the IL-15:IL-15RI? complex, produced by the same cell and 'trans-presented' to responder cells expressing the IL-15RI?I?c. The peculiar and almost unique requirement for IL-15 to be trans-presented by IL-15RI? suggests that the biological effects of IL-15 signaling are tightly regulated even at the level of availability of IL-15. Tissue-specific deletion of IL-15RI? has shown macrophage-and dendritic cell-derived IL-15RI? mediate the homeostasis of different CD8(+) T cell subsets. Here we show that hepatocyte and macrophage- specific expression of IL-15RI? is required to maintain the homeostasis of NK and NKT cells in the liver. Thus, homeostasis of IL-15-dependent lymphocyte subsets is also regulated by trans-presentation of IL-15 by non-hematopoietic cells in the tissue environment.

Author List

Cepero-Donates Y, Rakotoarivelo V, Mayhue M, Ma A, Chen YG, Ramanathan S

Author

Yi-Guang Chen PhD Professor in the Pediatrics department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Animals
CD8-Positive T-Lymphocytes
Dendritic Cells
Homeostasis
Interleukin-15
Liver
Macrophages
Mice
Mice, Knockout
Receptors, Interleukin-15
Signal Transduction