Faculty Collaboration Database

Metastatic adenocarcinoma after augmentation gastrocystoplasty. J Urol 2008 Mar;179(3):1094-6; discussion 1097

Date

01/22/2008

Pubmed ID

18206936

DOI

10.1016/j.juro.2007.10.089

Scopus ID

2-s2.0-39149133639 (requires institutional sign-in at Scopus site)   67 Citations

Abstract

PURPOSE: Augmentation gastrocystoplasty has been proposed as an alternative to enterocystoplasty because of potential benefits, including decreased risk of mucus production, stone formation and urinary tract infections. Although cancer has rarely been reported in this patient population, it is a well recognized potential risk of all augmentation cystoplasties. To define better the risk of malignancy associated with gastric augmentation and the appropriate surveillance protocol for these patients, we describe our experience in 2 patients with metastatic adenocarcinoma following gastrocystoplasty.

MATERIALS AND METHODS: We retrospectively reviewed the charts of all patients who had undergone augmentation gastrocystoplasty between 1990 and 1994. Of the 72 patients identified 2 were diagnosed with a primary malignancy arising from the augmented bladder. Charts were reviewed for medical history, clinical outcomes and pathology.

RESULTS: Two patients were identified with a primary bladder malignancy after gastrocystoplasty. Both patients had metastatic disease at initial presentation. Neither patient had a history of gross hematuria, recurrent urinary tract infections or pain before initial presentation. Mean patient age at augmentation was 5.5 years. Mean age at diagnosis of malignancy was 19.5 years, with a mean time from augmentation of 14 years.

CONCLUSIONS: Although the risk of bladder cancer is low after gastric augmentation, the effects may be life threatening. Therefore, we advocate routine annual surveillance with cystoscopy, bladder biopsy and upper tract imaging in all patients who have undergone augmentation gastrocystoplasty.

Author List

Vemulakonda VM, Lendvay TS, Shnorhavorian M, Joyner BD, Kaplan H, Mitchell ME, Grady RW

Author

Michael Ernst Mitchell MD Emeritus Professor in the Urology department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Adenocarcinoma
Adult
Anastomosis, Surgical
Child
Child, Preschool
Humans
Male
Retrospective Studies
Stomach
Stomach Neoplasms
Urethral Diseases
Urinary Bladder
Urinary Bladder Neoplasms
Urologic Diseases
Urologic Surgical Procedures