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The Relationship between Metformin and Obstructive Sleep Apnea. J Sleep Med Disord 2015;2(4)

Date

02/24/2016

Pubmed ID

26900606

Pubmed Central ID

PMC4756758

Abstract

OBJECTIVES: This study aimed to assess if metformin had any associations with the prevalence of obstructive sleep apnea in an adult type 2 diabetes population in the Midwest.

HYPOTHESIS: Use of metformin is associated with decreased prevalence of obstructive sleep apnea in a adult type 2 diabetes population.

METHODS: A retrospective secondary database analysis was carried out with metformin use by patients with type 2 diabetes as the primary variable of interest and obstructive sleep apnea status as the primary outcome. A sample population of 9,853 type 2 diabetes patients with one year of follow-up was used. Other variables that were analyzed included age, gender, race, hypertension, Congestive Heart Failure, Hemoglobin A1c (HbA1c), and Body Mass Index. A p-value of <0.01 was considered significant.

RESULTS: Metformin usage was not significantly associated with obstructive sleep apnea prevalence (Odds Ratio: 1.17, Confidence Interval: 1.00-1.36, p = 0.049), but trended in the direction where metformin usage was associated with having obstructive sleep apnea. Lower HbA1c was found to be significantly associated with lower prevalence of obstructive sleep apnea (p <0.001). The rest of the variables followed previously published associations.

CONCLUSIONS: Metformin therapy may improve sleep quality, but it may not be through methods that reduce the likelihood of developing obstructive sleep apnea. Future studies that can prove causation about this association should be considered.

Author List

Lin D, Rein L, Tarima S, Woodson BT, Meurer JR

Authors

John R. Meurer MD, MBA Institute Director, Professor in the Institute for Health and Equity department at Medical College of Wisconsin
Sergey S. Tarima PhD Associate Professor in the Institute for Health and Equity department at Medical College of Wisconsin
B Tucker Woodson MD Chief, Professor in the Otolaryngology department at Medical College of Wisconsin




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