Skeletal muscle respiratory capacity, endurance, and glycogen utilization. Am J Physiol 1975 Apr;228(4):1029-33
Date
04/01/1975Pubmed ID
165725DOI
10.1152/ajplegacy.1975.228.4.1029Scopus ID
2-s2.0-0016795518 (requires institutional sign-in at Scopus site) 165 CitationsAbstract
This study was undertaken to evaluate the relationship between physical performance capacity and the mitochondrial content of skeletal muscle. Four groups of rats were trained by means of treadmill running 5 days/wk for 13 wk. One group ran 10 min/day, a second group ran 30 min/day, a third group ran 60 min/day, and a fourth group ran 120 min/day. The magnitude of the exercise-induced adaptive increase in gastrocnemius muscle respiratory capacity varied over a twofold range in the four groups. There were significant correlations between the levels of three mitochondrial markers (cytochrome c, citrate synthase, respiratory capacity) in the animals' gastrocnemius muscles and the duration of a run to exhaustion. There was also a significant correlation between the amounts of glycogen remaining in liver and skeletal muscle after a 30-min-long exercise test and the respiratory capacity of the animal's leg muscles. These findings are compatible with the interpretation that a close relationshiop exists between skeletal muscle mitochondrial content and the capacity to perform endurance exercise.
Author List
Fitts RH, Booth FW, Winder WW, Holloszy JOAuthor
Robert Fitts PhD Professor in the Biological Sciences department at Marquette UniversityMESH terms used to index this publication - Major topics in bold
Adenosine DiphosphateAnimals
Citrate (si)-Synthase
Cytochrome c Group
Fatigue
Glycogen
History, 19th Century
Liver Glycogen
Male
Mitochondria, Muscle
Muscles
Oxygen Consumption
Phosphates
Physical Exertion
Pyruvates
Rats
