Medical College of Wisconsin
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Differential deoxyadenosine toxicity to immature rabbit cartilage in vitro. A model for the chondro-osseous dysplasia of adenosine deaminase deficiency. Arthritis Rheum 1989 Aug;32(8):1014-21

Date

08/01/1989

Pubmed ID

2788422

DOI

10.1002/anr.1780320811

Scopus ID

2-s2.0-0024450234 (requires institutional sign-in at Scopus site)   1 Citation

Abstract

Deoxyadenosine metabolism was investigated in rabbit growth plate and articular cartilage to elucidate the biochemical basis for the chondro-osseous dysplasia observed in adenosine deaminase (ADA) deficiency. Models of ADA deficiency, the combination of deoxy-adenosine and either of 2 ADA inhibitors, were selectively toxic to immature cartilage, supporting the hypothesis that the chondro-osseous dysplasia of ADA deficiency is the consequence of the enzyme deficiency. Depletion of ATP may play a role in the altered chondrocyte viability and function observed in this model.

Author List

Wortmann RL, Veum JA, Ryan LM, Cheung HS

Author

Lawrence M. Ryan MD Emeritus Professor in the Medicine department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Adenosine Deaminase
Adenosine Deaminase Inhibitors
Adenosine Triphosphate
Animals
Bone and Bones
Cartilage
Cell Survival
Deoxyadenosines
Disease Models, Animal
Nucleoside Deaminases
Purines
Rabbits