Left ventricular metabolism, function, and sympathetic innervation in men and women with type 1 diabetes. J Nucl Cardiol 2016 Oct;23(5):960-969
Date
05/06/2016Pubmed ID
27146882Pubmed Central ID
PMC5103640DOI
10.1007/s12350-016-0434-2Scopus ID
2-s2.0-84965008604 (requires institutional sign-in at Scopus site) 14 CitationsAbstract
BACKGROUND: In type I diabetes (T1DM), alterations in LV function may occur due to changes in innervation, metabolism, and efficiency.
OBJECTIVES: We evaluated the association between sympathetic nerve function, oxidative metabolism, resting blood flow, LV efficiency and function in healthy diabetics, and assessed gender differences.
METHODS: Cross-sectional study of 45 subjects with T1DM, 60% females, age 34 ± 13 years, and 10 age-matched controls. Positron emission tomography (PET) imaging with [(11)C]acetate and [(11)C]meta-hydroxyephedrine was performed, in addition to cardiac magnetic resonance imaging.
RESULTS: There were no significant differences in LV function, innervation, or oxidative metabolism between T1DM and controls. Cardiac oxidative metabolism was positively associated with higher levels of sympathetic activation, particularly in women. Diabetic women had significantly lower efficiency compared with diabetic men. Resting flow was significantly higher in diabetic women compared with diabetic men, and tended to be higher in female controls as well.
CONCLUSIONS: Measures of myocardial function, metabolism, blood flow, and sympathetic activation were preserved in young, otherwise healthy, T1DM patients. However, T1DM women presented with greater myocardial oxidative metabolism requirements than men. Ongoing studies are evaluating changes over time.
Author List
Duvernoy CS, Raffel DM, Swanson SD, Jaiswal M, Mueller G, Ibrahim ES, Pennathur S, Plunkett C, Stojanovska J, Brown MB, Pop-Busui RMESH terms used to index this publication - Major topics in bold
AdultBlood Flow Velocity
Coronary Circulation
Diabetes Mellitus, Type 1
Diabetic Cardiomyopathies
Ephedrine
Female
Heart Ventricles
Humans
Male
Reproducibility of Results
Sensitivity and Specificity
Sex Characteristics
Stroke Volume
Sympathetic Nervous System
Ventricular Dysfunction, Left
