Cardiac Magnetic Resonance Imaging in Pediatric Turner Syndrome. J Pediatr 2016 Aug;175:111-115.e1
Date
05/29/2016Pubmed ID
27233524DOI
10.1016/j.jpeds.2016.04.080Scopus ID
2-s2.0-84971657336 (requires institutional sign-in at Scopus site) 6 CitationsAbstract
OBJECTIVE: To compare the detection of cardiac lesions with the use of cardiac magnetic resonance imaging (CMR) and conventional echocardiography in children with Turner syndrome.
STUDY DESIGN: Twenty-four girls with Turner syndrome, 8-18 years of age, were recruited through the Pediatric Endocrinology Program. Participants underwent CMR and echocardiography within a 2-year period, and discrepancies between the results of each modality were identified.
RESULTS: Fifteen of 24 (63%) girls had a cardiac lesion identified on CMR or echocardiography. Both modalities identified the same lesion in 10 of 15 (67%); however, 6 of 15 (40%) participants had a lesion identified on CMR but not echocardiography. Participants with a missed lesion had a trend towards greater body mass index. Aortic dilation and bicuspid aortic valve were the most commonly missed lesions by echocardiography.
CONCLUSIONS: CMR identifies significant cardiac lesions missed by echocardiography in pediatric patients with Turner syndrome, particularly along the aorta. These findings support the current guidelines that recommend screening CMR in addition to echocardiogram. Early identification of cardiac abnormalities in patients with Turner syndrome will allow for a greater understanding of the natural history in these patients and potentially identify candidates for earlier intervention.
Author List
Somerville S, Rosolowsky E, Suntratonpipat S, Girgis R, Goot BH, Tham EBAuthor
Ben Goot MD Associate Professor in the Pediatrics department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AdolescentChild
Cross-Sectional Studies
Echocardiography
Female
Heart
Humans
Magnetic Resonance Imaging
Turner Syndrome