Unilateral odor deprivation: effects on the development of staining for olfactory bulb succinate dehydrogenase. Brain Res 1987 Sep;432(1):35-42
Date
09/01/1987Pubmed ID
2820549DOI
10.1016/0165-3806(87)90006-xScopus ID
2-s2.0-0023205321 (requires institutional sign-in at Scopus site) 36 CitationsAbstract
Littermate rat pups underwent either unilateral surgical occlusion of the right external naris or sham surgery on postnatal Day 1. At 4-, 8-, 12-, 20- or 30-days postpartum, olfactory bulb sections were histochemically reacted to reveal either succinate dehydrogenase (SDH) or cytochrome oxidase (CO) activity. Microdensitometry was used to determine levels of staining in glomeruli and the external plexiform layer at standardized locations within the bulb. In experimental subjects asymmetries in left/right bulb SDH staining patterns were detected as early as Day 4, suggesting that the deprivation procedure resulted in quite rapid changes in the metabolic function of olfactory bulb cells. Control animals did not exhibit left/right differences in bulb staining, but inter-glomerular and regional variations in staining were observed throughout the early developmental period. Understanding these early variations in metabolic activity may be important for a complete understanding of olfactory bulb maturation.
Author List
Cullinan WE, Brunjes PCAuthor
William E. Cullinan PhD Adjunct Associate Professor in the Neurosurgery department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AnimalsElectron Transport Complex IV
Histocytochemistry
Nose
Odorants
Olfactory Bulb
Rats
Sensory Deprivation
Smell
Succinate Dehydrogenase
