Neutrophil accumulation and cutaneous responses in experimental cutaneous candidiasis of genetically complement-deficient mice. Clin Immunol Immunopathol 1988 Feb;46(2):284-93
Date
02/01/1988Pubmed ID
2827924DOI
10.1016/0090-1229(88)90190-0Scopus ID
2-s2.0-0023955760 (requires institutional sign-in at Scopus site) 10 CitationsAbstract
Mice deficient in the fifth component of complement were studied for their ability to respond to and clear experimental cutaneous Candida albicans infections. The complement-deficient animals took longer to clear the infections and developed a significantly greater delayed hypersensitivity response to Candida than did normal animals. However, although the serum of the complement-deficient animals was incapable of generating in vitro chemotactic activity for neutrophils after appropriate stimulation, the epidermal neutrophilic infiltrate in the Candida-infected skin of these animals was equivalent to that in the normal animals. The progression of the infection, including the early relocation of the invading Candida pseudohyphae to a more superficial site in the stratum corneum and the thickening of the epidermis itself, was also similar in the complement-deficient and normal animals. Therefore, although mice lacking the fifth complement component cannot generate complement-derived serum chemotactic factors and are somewhat less efficient in clearing experimental cutaneous candidiasis, the accumulation of neutrophils in the Candida-infected skin of these animals and their initial cutaneous responses to the infections are normal.
Author List
Wilson BD, Sohnle PGAuthor
Peter G. Sohnle MS, MD Emeritus Professor in the Medicine department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AbscessAnimals
Candida albicans
Candidiasis, Cutaneous
Chemotaxis, Leukocyte
Complement C5
Complement System Proteins
Hypersensitivity, Delayed
Mice
Neutrophils
Peroxidase
