The function of SH2B3 (LNK) in the kidney. Am J Physiol Renal Physiol 2016 Oct 01;311(4):F682-F685
Date
07/22/2016Pubmed ID
27440780Pubmed Central ID
PMC5142233DOI
10.1152/ajprenal.00373.2016Scopus ID
2-s2.0-84989893177 (requires institutional sign-in at Scopus site) 8 CitationsAbstract
Recent evidence indicates the adaptor protein SH2B3 has a major role in the progression of renal diseases. SH2B3 is highly expressed by hematopoietic cells and regulates cytokine signaling, inducing cell-specific effects. Additionally, its expression in other cell types suggests that SH2B3 may have a more extensive role within the kidney. Ex vivo studies have determined targets of SH2B3 cell-specific signaling, while in vivo studies have observed the SH2B3 overall affects in the progression of renal diseases. This mini-review covers the function of SH2B3-expressing cell types that contribute to renal pathologies and their regulation by SH2B3.
Author List
Blass G, Mattson DL, Staruschenko AMESH terms used to index this publication - Major topics in bold
Adaptor Proteins, Signal TransducingAnimals
Humans
Intracellular Signaling Peptides and Proteins
Kidney
Kidney Diseases
Proteins
Signal Transduction