Comparison of swallowing function after intensity-modulated radiation therapy and conventional radiotherapy for head and neck cancer. Head Neck 2015 Nov;37(11):1575-82
Date
06/10/2014Pubmed ID
24909649Pubmed Central ID
PMC4258519DOI
10.1002/hed.23796Scopus ID
2-s2.0-84944148731 (requires institutional sign-in at Scopus site) 43 CitationsAbstract
BACKGROUND: Intensity-modulated radiotherapy (IMRT) is hoped to protect structures important for swallow function. We compared posttreatment swallow function in 7 pairs of patients with head and neck cancer treated with either IMRT or conventional radiotherapy (RT).
METHODS: Patients were matched on tumor characteristics. Swallowing function was evaluated with the modified barium swallow procedure pretreatment and at 3 and 6 months postcancer treatment completion. Swallows were analyzed for bolus transit times, bolus residues, laryngeal closure (LAC) duration, cricopharyngeal opening (CPO) duration, and oropharyngeal swallow efficiency (OPSE). Data were analyzed using multifactor repeated measures analysis of variance and adjusted for baseline function.
RESULTS: Main effect of radiation type was significant for all measures on at least 1 bolus type. Patients treated with IMRT demonstrated shorter bolus transit times, less oral and pharyngeal residue, longer LAC, and larger OPSE.
CONCLUSION: Patients treated with IMRT demonstrated faster, more efficient swallows, and greater airway protection.
Author List
Pauloski BR, Rademaker AW, Logemann JA, Discekici-Harris M, Mittal BBAuthor
Barbara R. Pauloski PhD, CCC-SLP Associate Professor in the Communication Sciences & Disorders department at University of Wisconsin - MilwaukeeMESH terms used to index this publication - Major topics in bold
AdultAged
Chemotherapy, Adjuvant
Cohort Studies
Deglutition
Deglutition Disorders
Disease-Free Survival
Female
Follow-Up Studies
Head and Neck Neoplasms
Humans
Male
Middle Aged
Nasopharyngeal Neoplasms
Oropharyngeal Neoplasms
Radiotherapy Dosage
Radiotherapy, Intensity-Modulated
Retrospective Studies
Risk Assessment
Survival Analysis
Treatment Outcome
