Effect of induction chemotherapy on swallow physiology and saliva production in patients with head and neck cancer: a pilot study. Head Neck 2015 Apr;37(4):567-72
Date
03/29/2014Pubmed ID
24677442Pubmed Central ID
PMC4139482DOI
10.1002/hed.23635Scopus ID
2-s2.0-84925594494 (requires institutional sign-in at Scopus site) 14 CitationsAbstract
BACKGROUND: No objective data are available to assess the potential damage induction chemotherapy alone contributes to swallowing physiology and salivary production in patients with locally and regionally confined head and neck cancer.
METHODS: Thirteen patients with head and neck cancer were evaluated preinduction and postinduction chemotherapy. Assessment included: (1) percentage of nutrition taken orally and food consistencies in diet; (2) videofluorographic swallow evaluation; (3) whole mouth saliva collection; (4) quality-of-life questionnaire; and (5) pain and oral mucositis scores.
RESULTS: All patients were able to consume most foods and took 100% of their nutrition orally both preinduction and postinduction chemotherapy. Although a number of swallow measures worsened, no statistically significant differences were observed in diet, quality of life measures, pain, or saliva weight, or in most temporal swallow measures. Pharyngeal residue decreased significantly after chemotherapy.
CONCLUSION: Induction chemotherapy alone did not significantly negatively alter swallowing physiology and salivary secretion, although the trend was toward worsening in function.
Author List
Mittal BB, Pauloski BR, Rademaker AW, Discekici-Harris M, Helenowski IB, Mellot A, Agulnik M, Logemann JAAuthor
Barbara R. Pauloski PhD, CCC-SLP Associate Professor in the Communication Sciences & Disorders department at University of Wisconsin - MilwaukeeMESH terms used to index this publication - Major topics in bold
AdultAged
Deglutition
Female
Head and Neck Neoplasms
Humans
Induction Chemotherapy
Male
Middle Aged
Pilot Projects
Prospective Studies
Quality of Life
Stomatitis
