Resting state corticolimbic connectivity abnormalities in unmedicated bipolar disorder and unipolar depression. Psychiatry Res 2009 Mar 31;171(3):189-98
Date
02/24/2009Pubmed ID
19230623Pubmed Central ID
PMC3001251DOI
10.1016/j.pscychresns.2008.03.012Scopus ID
2-s2.0-61349175176 (requires institutional sign-in at Scopus site) 306 CitationsAbstract
This study for the first time investigated resting state corticolimbic connectivity abnormalities in unmedicated bipolar disorder (BD) and compared them with findings in healthy controls and unipolar major depressive disorder (MDD) patient groups. Resting state correlations of low frequency BOLD fluctuations (LFBF) in echoplanar functional magnetic resonance (fMRI) data were acquired from a priori defined regions of interests (ROIs) in the pregenual anterior cingulate cortex (pgACC), dorsomedial thalamus (DMTHAL), pallidostriatum (PST) and amygdala (AMYG), to investigate corticolimbic functional connectivity in unmedicated BD patients in comparison to healthy subjects and MDD patients. Data were acquired from 11 unmedicated BD patients [six manic (BDM) and five depressed (BDD)], and compared with data available from 15 unmedicated MDD and 15 healthy subjects. BD patients had significantly decreased pgACC connectivity to the left and right DMTHAL, similar to findings seen in MDD. Additionally, BD patients had decreased pgACC connectivity with the left and right AMYG as well as the left PST. An exploratory analysis revealed that both BDD and BDM patients had decreased connectivity between the pgACC and DMTHAL. The results of the study indicate a common finding of decreased corticolimbic functional connectivity in different types of mood disorders.
Author List
Anand A, Li Y, Wang Y, Lowe MJ, Dzemidzic MAuthor
Yang Wang MD Professor in the Radiology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AdultAmygdala
Arousal
Bipolar Disorder
Brain Mapping
Cerebral Cortex
Corpus Callosum
Corpus Striatum
Dominance, Cerebral
Female
Globus Pallidus
Gyrus Cinguli
Humans
Image Processing, Computer-Assisted
Limbic System
Magnetic Resonance Imaging
Male
Mediodorsal Thalamic Nucleus
Middle Aged
Nerve Net
Oxygen Consumption
Reference Values
Young Adult
