Neutrophil death as a defence mechanism against Candida albicans infections. Lancet 1988 Nov 19;2(8621):1163-5
Date
11/19/1988Pubmed ID
2903377DOI
10.1016/s0140-6736(88)90234-6Scopus ID
2-s2.0-0023815341 (requires institutional sign-in at Scopus site) 59 CitationsAbstract
In studies of experimental Candida albicans infections, growth of invading organisms sometimes ceased before the organisms reached the neutrophil infiltrates. Lysates of human neutrophils inhibited the directed growth of candida pseudohyphae in agarose gel and suppressed the proliferation of candida yeast in broth cultures, but did not kill the organisms or prevent their germination. The growth-inhibitory material released from disrupted neutrophils had an estimated molecular weight of 30 kD and differed from most previously described neutrophil antimicrobial factors in that it was present in cell sap rather than granules, and did not appear in the supernatant after stimulation of the cells. Neutrophil death and dissolution may represent an alternative host defence mechanism against invasive C albicans infection.
Author List
McNamara MP, Wiessner JH, Collins-Lech C, Hahn BL, Sohnle PGAuthor
Peter G. Sohnle MS, MD Emeritus Professor in the Medicine department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AnimalsBlood Bactericidal Activity
Candida albicans
Candidiasis
Cell Survival
Chromatography, Gel
Colony Count, Microbial
Growth Inhibitors
Humans
In Vitro Techniques
Mice
Mice, Inbred C57BL
Molecular Weight
Neutrophils
