The classical and alternate pathways of T cell activation are impaired in leprosy. Immunol Lett 1988 Sep;19(1):55-8
Date
09/01/1988Pubmed ID
2903849DOI
10.1016/0165-2478(88)90119-8Scopus ID
2-s2.0-0023687271 (requires institutional sign-in at Scopus site) 4 CitationsAbstract
The proliferative response of circulating T lymphocytes from bacterial index-positive lepromatous patients to mitogenic anti-CD3 and pairs of anti-CD2 monoclonal antibodies was significantly reduced. In these patients, the CD2 but not CD3 receptor expression was down-regulated. Further, the CD2 modulation and the associated suppression of proliferative response to monoclonals was brought about in T cells of healthy subjects by prior incubation of mononuclear cells in vitro with Mycobacterium leprae. Thus, the T cell activation pathways through the CD3 and CD2 receptors are impaired in lepromatous leprosy patients and the impairment appears to be due to the modulation of the CD2 receptor specifically by M. leprae.
Author List
Muthukkaruppan V, Chakkalath HR, Malarkannan SAuthor
Subramaniam Malarkannan PhD Professor in the Medicine department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
Antibodies, MonoclonalAntigens, Differentiation, T-Lymphocyte
CD2 Antigens
CD3 Complex
Humans
Immune Tolerance
In Vitro Techniques
Leprosy
Lymphocyte Activation
Mycobacterium leprae
Receptors, Antigen, T-Cell
Receptors, Immunologic
T-Lymphocytes
