Glycans and the platelet life cycle. Platelets 2016 Sep;27(6):505-11
Date
05/03/2016Pubmed ID
27135356Pubmed Central ID
PMC5396182DOI
10.3109/09537104.2016.1171304Scopus ID
2-s2.0-84965011455 (requires institutional sign-in at Scopus site) 59 CitationsAbstract
Platelet numbers are intricately regulated to avoid spontaneous bleeding or arterial occlusion and organ damage. The growth factor thrombopoietin (TPO) drives platelet biogenesis by inducing megakaryocyte production. A recent study in mice identified a feedback mechanism by which clearance of aged, desialylated platelets stimulates TPO synthesis by hepatocytes. This new finding generated renewed interest in platelet clearance mechanisms. Here, different established and emerging mechanisms of platelet senescence and clearance will be reviewed with specific emphasis on the role of posttranslational modifications.
Author List
Li R, Hoffmeister KM, Falet HAuthors
Herve Falet PhD Associate Professor in the Cell Biology, Neurobiology and Anatomy department at Medical College of WisconsinKarin Hoffmeister MD Professor in the Biochemistry department at Medical College of Wisconsin
MESH terms used to index this publication - Major topics in bold
AnimalsApoptosis
Blood Platelet Disorders
Blood Platelets
Carrier Proteins
Cellular Senescence
Glycoside Hydrolases
Humans
Lectins
Liver
Lysosomes
Platelet Glycoprotein GPIb-IX Complex
Platelet Membrane Glycoproteins
Polysaccharides
Protein Binding