New insights into the versatile roles of platelet FlnA. Platelets 2013;24(1):1-5
Date
03/01/2012Pubmed ID
22372530Pubmed Central ID
PMC6781629DOI
10.3109/09537104.2011.654004Scopus ID
2-s2.0-84871764376 (requires institutional sign-in at Scopus site) 26 CitationsAbstract
Recent findings have identified critical roles for the actin filament-crosslinking protein filamin A (FlnA) in platelets and megakaryocytes. This short review focuses on the structure of FlnA and its interaction with the Von Willebrand Factor receptor GPIb-IX-V complex and the fibrinogen receptor, the integrin αIIbβ3 in platelets.
Author List
Falet HAuthor
Herve Falet PhD Associate Professor in the Cell Biology, Neurobiology and Anatomy department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
Blood PlateletsCarrier Proteins
Contractile Proteins
Filamins
Humans
Microfilament Proteins
Mutation
Protein Binding
Thrombocytopenia