Faculty Collaboration Database

Olfactory bulbectomy prevents short photoperiod-induced anestrus in female golden hamsters. Brain Res 1986 Aug 13;380(1):54-8

Date

08/13/1986

Pubmed ID

3092990

DOI

10.1016/0006-8993(86)91428-9

Scopus ID

2-s2.0-0022529470 (requires institutional sign-in at Scopus site)   5 Citations

Abstract

When female golden hamsters are maintained on a photoperiod of less than 12.5 h of light per day, they go into a pineal gland-induced anestrus in 6-10 weeks. This acyclicity is similar in certain respects to the testicular regression which occurs in male golden hamsters maintained on a short photoperiod. A recent study has indicated that pre-pubertal olfactory bulbectomy (BX) will prevent the testicular regression in adult male hamsters exposed to a short photoperiod. The present study tested the effect of pre-pubertal or adult BX on the anestrus associated with maintenance of adult female golden hamsters on short photoperiod. In Expt. 1, hamsters were pre-pubertally sham BX (SH) or BX (23-25 days of age) and then maintained on LD 14:10 or LD 6:18 for 15 weeks. In Expt. 2, hamsters were SH or BX as adults (63-65 days of age) and maintained on LD 6:18 for 13 weeks. The estrous cycles of all animals were monitored on a daily basis. In Expt. 1, all animals on LD 14:10 had regular estrous cycles for the duration of the study. Sixty percent of the SH group on LD 6:18 became anestrous, whereas 87.5% of the BX group on LD 6:18 continued having regular cycles. In Expt. 2, 80% of the SH group became anestrous while 90% of the BX group continued having regular estrous cycles. The possible mechanisms whereby BX affects the cyclicity of female hamsters is discussed. The fact that BX resulted in increased morning gonadotropin levels and ovarian weight in animals on LD 14:10, as well as in the hamsters on short photoperiod, suggests that there is a relationship between the olfactory bulb and the reproductive system that is independent of the photoperiod, in addition to more dramatic effects of olfaction on reproduction in animals on a short photoperiod.

Author List

Pieper DR, Samyn MM, Heverly RN

Author

Margaret Mary Samyn MD, MBA Assistant Dean, Professor in the Pediatrics department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Anestrus
Animals
Circadian Rhythm
Cricetinae
Estrus
Female
Follicle Stimulating Hormone
Luteinizing Hormone
Mesocricetus
Olfactory Bulb
Organ Size
Time Factors