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Premenstrual Syndrome and Premenstrual Dysphoric Disorder. Am Fam Physician 2016 Aug 01;94(3):236-40



Pubmed ID


Scopus ID

2-s2.0-84979710733 (requires institutional sign-in at Scopus site)   114 Citations


Premenstrual disorders affect up to 12% of women. The subspecialties of psychiatry and gynecology have developed overlapping but distinct diagnoses that qualify as a premenstrual disorder; these include premenstrual syndrome and premenstrual dysphoric disorder. These conditions encompass psychological and physical symptoms that cause significant impairment during the luteal phase of the menstrual cycle, but resolve shortly after menstruation. Patientdirected prospective recording of symptoms is helpful to establish the cyclical nature of symptoms that differentiate premenstrual syndrome and premenstrual dysphoric disorder from other psychiatric and physical disorders. Physicians should tailor therapy to achieve the greatest functional improvement possible for their patients. Select serotonergic antidepressants are first-line treatments. They can be used continuously or only during the luteal phase. Oral contraceptives and calcium supplements may also be used. There is insufficient evidence to recommend treatment with vitamin D, herbal remedies, or acupuncture, but there are data to suggest benefit from cognitive behavior therapy.

Author List

Hofmeister S, Bodden S


Seth Bodden MD Assistant Professor in the Family Medicine department at Medical College of Wisconsin
Sabrina L. Hofmeister DO Associate Professor in the Family Medicine department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Contraceptives, Oral, Hormonal
Dietary Supplements
Premenstrual Dysphoric Disorder
Premenstrual Syndrome