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Epinephrine inhibits invasion of oral squamous carcinoma cells by modulating intracellular cAMP. Cancer Lett 2002 Feb 25;176(2):143-8

Date

01/24/2002

Pubmed ID

11804741

DOI

10.1016/s0304-3835(01)00764-9

Scopus ID

2-s2.0-0037169861 (requires institutional sign-in at Scopus site)   29 Citations

Abstract

In oral and maxillofacial surgery, epinephrine is routinely used for cancer resection and it is important to clarify the effects of this agent on cancer. We found here that the clinically relevant concentrations of epinephrine (10, 50 and 100 microg/ml) decreased the invasion ability of oral squamous carcinoma (Sa3) cells. In the Sa3 cells treated with epinephrine (10, 50 and 100 microg/ml), migration, morphological changes and formation of actin stress fibers were inhibited and intracellular cyclic adenosine monophosphate (cAMP) increased significantly. These findings suggest that epinephrine inhibits the invasion of cancer cells by modulating intracellular cAMP and that clinicians could use epinephrine effectively for the surgical resection of the cancer.

Author List

Yamanaka Y, Mammoto T, Kirita T, Mukai M, Mashimo T, Sugimura M, Kishi Y, Nakamura H

Author

Tadanori Mammoto MD, PhD Associate Professor in the Pediatrics department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Actins
Adrenergic Agonists
Cell Movement
Cyclic AMP
Dose-Response Relationship, Drug
Epinephrine
Humans
Microscopy, Fluorescence
Mouth Neoplasms
Neoplasm Invasiveness
Neoplasms, Squamous Cell
Time Factors
Tumor Cells, Cultured
Wound Healing