Effects of anticipated neonatal surgical intervention on maternal milk cytokine production. J Pediatr Surg 2017 Jan;52(1):45-49
Date
11/12/2016Pubmed ID
27836369DOI
10.1016/j.jpedsurg.2016.10.017Scopus ID
2-s2.0-85006269815 (requires institutional sign-in at Scopus site) 3 CitationsAbstract
BACKGROUND: Maternal stress on neonatal outcomes of infants admitted to the NICU is incompletely understood. We previously demonstrated breast milk derived cytokines remain biologically active in the neonatal intestine. We hypothesized that the need for neonatal surgical intervention would be stimulus leading to maternal cytokine production thus affecting neonatal outcome.
METHODS: Discarded expressed breast milk (EBM) in the first 3weeks following delivery was analyzed for IL-23 and IL-10 by ELISA. Variables analyzed included: the need for a pediatric surgical procedure, the need for cardiac surgical procedure, no surgical interventions, and survival. All values are expressed as meanĀ±SEM. Statistical analysis utilized Kruskal and Mann-Whitney test.
RESULTS: EBM from mothers whose infants required any surgical procedure (n=19) revealed significant elevation in IL-10 but not IL-23 compared to nonsurgical EBM (n=18). Subdivided by procedure type, there was no difference between those undergoing a cardiac (n=9) versus pediatric surgical (n=10) procedure in both IL-10 and IL-23. Mothers whose infants requiring surgical intervention or whose infants did not survive in the first 3weeks of life had elevation of IL-10.
CONCLUSION: Results suggest maternal stress impacts the cytokine profile of breast milk.
LEVEL OF EVIDENCE: Level III.
Author List
Rentea RM, Wagner AJ, Gourlay DM, Christensen M, Liedel JLAuthors
David M. Gourlay MD Chief, Professor in the Surgery department at Medical College of WisconsinAmy Wagner MD Professor in the Surgery department at Medical College of Wisconsin
MESH terms used to index this publication - Major topics in bold
Anticipation, PsychologicalFemale
Humans
Infant, Newborn
Interleukin-10
Interleukin-23
Milk, Human
Mothers
Stress, Psychological
Surgical Procedures, Operative