1/f fluctuations in arterial pressure and regulation of renal blood flow in dogs. Am J Physiol 1990 May;258(5 Pt 2):F1394-400
Date
05/11/1990Pubmed ID
2337155DOI
10.1152/ajprenal.1990.258.5.F1394Scopus ID
2-s2.0-0025288118 (requires institutional sign-in at Scopus site) 94 CitationsAbstract
To determine whether renal blood flow is regulated against spontaneous fluctuations in arterial pressure and to estimate the frequency band of the regulation, we measured arterial pressure and renal blood flow continuously over several days in conscious dogs. Mean arterial blood pressure showed broad band fluctuations and behaved as a 1/f process, indicating that the blood pressure record is a fractal curve and therefore scale invariant. The fluctuations in arterial pressure caused attenuated fluctuations in renal blood flow; the gain was about -6.5 +/- 0.5 dB through all sampled frequencies greater than or equal to 4 cycle/day. The kidney did not attenuate the blood pressure signal at the lowest frequencies. The results show that renal blood flow is better regulated against fluctuations in pressure at frequencies greater than or equal to 4 cycle/day than it is at lower frequencies. Although there are no direct tests of the underlying regulatory mechanisms, we argue that the responses are generated locally and can be identified with renal autoregulation.
Author List
Marsh DJ, Osborn JL, Cowley AW JrAuthor
Allen W. Cowley Jr PhD Professor in the Physiology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
Activity CyclesAnimals
Blood Pressure
Dogs
Female
Mathematics
Renal Circulation
Spectrum Analysis