Faculty Collaboration Database

Long-term blood pressure and metabolic effects of vasopressin with servo-controlled fluid volume. Am J Physiol 1984 Sep;247(3 Pt 2):R537-45

Date

09/11/1984

Pubmed ID

6383081

DOI

10.1152/ajpregu.1984.247.3.R537

Scopus ID

2-s2.0-0021487509 (requires institutional sign-in at Scopus site)   30 Citations

Abstract

Studies were performed in normal mongrel dogs (n = 8) to assess whether changes observed with chronic administration of vasopressin (AVP) were a result of direct actions of AVP or the consequence of changes in body fluid volume. AVP was infused continuously for 2 wk (0.36 ng X kg-1 X min-1 iv), while total body weight and body water (TBW) were maintained constant (+/- 50 g) using a servo-controlled system. A metabolic cage was mounted on sensitive force transducers for continuous monitoring of TBW. The summed voltage output of these transducers was used to servo control an intravenous infusion pump that adjusted the rate of water intake required for maintenance of a constant TBW. AVP infused under these conditions chronically increased plasma AVP levels from 2 to 22 pg/ml but resulted in no change of average 24-h mean arterial pressure, plasma sodium, or osmolality. Urine excretion decreased from 800 to 200 ml/day, whereas urine osmolality increased from 430 to 1,200 mosmol/kg and remained at these levels throughout the 2-wk AVP infusion. A net loss of 20 meq sodium occurred during the 1st day of AVP infusion but thereafter was unchanged. Plasma sodium and osmolality were unchanged from control during AVP infusions. We conclude that AVP-induced changes of arterial pressure, plasma sodium concentration and osmolality, renal escape, suppression of renin activity, and most of the observed natriuresis are events normally dependent on volume expansion.

Author List

Cowley AW Jr, Merrill DC, Quillen EW Jr, Skelton MM

Author

Allen W. Cowley Jr PhD Professor in the Physiology department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Aldosterone
Animals
Arginine Vasopressin
Blood Pressure
Body Water
Body Weight
Diuresis
Dogs
Metabolism
Osmolar Concentration
Physiology
Potassium
Renin
Sodium
Time Factors
Urea