Roscoe Owen Brady, MD: Remembrances of co-investigators and colleagues. Mol Genet Metab 2017;120(1-2):1-7
Date
11/22/2016Pubmed ID
27866832DOI
10.1016/j.ymgme.2016.10.010Scopus ID
2-s2.0-85006830465 (requires institutional sign-in at Scopus site) 2 CitationsAbstract
To celebrate the research visions and accomplishments of the late Roscoe O. Brady (1923-2016), remembrance commentaries were requested from several of his postdoctoral research fellows and colleagues. These commentaries not only reflect on the accomplishments of Dr. Brady, but they also share some of the backstories and experiences working in the Brady laboratory. They provide insights and perspectives on Brady's research activities, and especially on his efforts to develop an effective treatment for patients with Type 1 Gaucher disease. These remembrances illuminate Brady's efforts to implement the latest scientific advances with an outstanding team of young co-investigators to develop and demonstrate the safety and effectiveness of the first enzyme replacement therapy for a lysosomal storage disease. Brady's pursuit and persistence in accomplishing his research objectives provide insights into this remarkably successful physician scientist who paved the way for the development of treatments for patients with other lysosomal storage diseases.
Author List
Desnick RJ, Barton NW, Furbish S, Grabowski GA, Karlsson S, Kolodny EH, Medin JA, Murray GJ, Mistry PK, Patterson MC, Schiffmann R, Weinreb NJAuthor
Jeffrey A. Medin PhD Professor in the Pediatrics department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
Enzyme Replacement TherapyGaucher Disease
History, 20th Century
History, 21st Century
Humans
Lysosomal Storage Diseases
Research Personnel