Usual and Unusual Manifestations of Familial Hemophagocytic Lymphohistiocytosis and Langerhans Cell Histiocytosis. Pediatr Clin North Am 2017 Feb;64(1):91-109
Date
11/30/2016Pubmed ID
27894453DOI
10.1016/j.pcl.2016.08.006Scopus ID
2-s2.0-84998773661 (requires institutional sign-in at Scopus site) 13 CitationsAbstract
Familial hemophagocytic lymphohistiocytosis (FHL) and Langerhans cell histiocytosis (LCH) are histiocytic diseases that occur most commonly in young children. Improvements in recognition and treatment have been substantial for both diseases in the past decade, although early and late morbidity continue to be major concerns. These two diagnoses behave differently, although the clinical spectra for both diseases are diverse and can lead to confusion and delays in diagnosis and treatment. This article focuses on the clinical and genetic spectrum of FHL as well as the clinical and treatment variations of LCH.
Author List
Erker C, Harker-Murray P, Talano JAAuthors
Paul D. Harker-Murray PhD, MD Professor in the Pediatrics department at Medical College of WisconsinJulie-An M. Talano MD Professor in the Pediatrics department at Medical College of Wisconsin
MESH terms used to index this publication - Major topics in bold
ChildDelayed Diagnosis
Diagnosis, Differential
Diagnostic Errors
Histiocytosis, Langerhans-Cell
Humans
Lymphohistiocytosis, Hemophagocytic
Rare Diseases
