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Differentiating Familial Neuropathies from Guillain-Barré Syndrome. Pediatr Clin North Am 2017 Feb;64(1):231-252

Date

11/30/2016

Pubmed ID

27894447

DOI

10.1016/j.pcl.2016.08.015

Scopus ID

2-s2.0-84998865507 (requires institutional sign-in at Scopus site)   3 Citations

Abstract

Differentiating Guillain-Barré syndrome (GBS) from inherited neuropathies and other acquired peripheral neuropathies requires understanding the atypical presentations of GBS and its variant forms, as well as historical and physical features suggestive of inherited neuropathies. GBS is typically characterized by the acute onset of ascending flaccid paralysis, areflexia, and dysesthesia secondary to peripheral nerve fiber demyelination. The disorder usually arises following a benign gastrointestinal or respiratory illness, is monophasic, reaches a nadir with several weeks, and responds to immunomodulatory therapy. Inherited neuropathies with onset before adulthood, whose presentation may mimic Guillain-Barré syndrome, are reviewed.

Author List

Bordini BJ, Monrad P

Author

Brett J. Bordini MD Associate Professor in the Pediatrics department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Child
Diagnosis, Differential
Guillain-Barre Syndrome
Humans
Immunomodulation
Immunotherapy
Peripheral Nervous System Diseases