Faculty Collaboration Database

Quality of life of older African American breast cancer survivors: a population-based study. Support Care Cancer 2017 May;25(5):1431-1438

Date

12/18/2016

Pubmed ID

27987093

Pubmed Central ID

PMC7064808

DOI

10.1007/s00520-016-3539-x

Scopus ID

2-s2.0-85006341699 (requires institutional sign-in at Scopus site)   14 Citations

Abstract

INTRODUCTION: Factors associated with lower health-related quality of life (HRQOL) among older African American (AA) breast cancer survivors (BCS) have not been elucidated.

METHODS: Using the Surveillance, Epidemiology, and End Results-Medicare Health Outcome Survey linked dataset, all resected AA BCS over 65 were identified. Using the most recent survey after diagnosis, individuals with a VR12 physical (PCS) or mental (MCS) component score 10 points lower than the median were categorized as having poor HRQOL. Univariate and multivariate (MV) analyses identified predictors of poor HRQOL.

RESULTS: Of 373 AA BCS (median age 74.6), median time from diagnosis to survey was 68.4 months with median follow-up of 138.6 months. Median PCS was 35.9 (IQR 28.5-44.5) with 76 (20.1%) reporting poor PCS. Median MCS was 50.6 (IQR 41.3-59.1) with 101 (27.1%) reporting poor MCS. Predictors of poor PCS included advanced age, larger tumor size, ≥2 comorbidities, inability to perform >2 of 6 activities of daily living (ADLs), modified/radical mastectomy, infiltrating lobular carcinoma, and stage III or IV disease (all p < 0.05). Comorbidities ≥2 and inability to perform >2 of 6 ADLs (p < 0.05) predicted poor MCS. Inability to perform >2 of 6 ADLs was the only independent predictor of poor PCS (OR 10.9, 95% CI 3.0-39.3; p < 0.001) and MCS (OR 7.6, 95% CI 4.3-13.3; p < 0.001).

CONCLUSION: In elderly AA BCS, poor HRQOL was not associated with socioeconomic status or tumor-specific factors but rather impairment in ADLs. Physical and mental HRQOL in African American breast cancer survivors is not dependent on socioeconomic or tumor-related characteristics, but rather on inability to perform ADLs.

Author List

Mogal HD, Howard-McNatt M, Dodson R, Fino NF, Clark CJ

MESH terms used to index this publication - Major topics in bold

Activities of Daily Living
Age Factors
Aged
Breast Neoplasms
Cohort Studies
Female
Health Surveys
Humans
Male
Middle Aged
Multivariate Analysis
Neoplasm Staging
Quality of Life
Retrospective Studies
Survivors