In vitro binding experiments with a Valerian, hops and their fixed combination extract (Ze91019) to selected central nervous system receptors. Phytomedicine 2004 Nov;11(7-8):633-8
Date
01/08/2005Pubmed ID
15636177DOI
10.1016/j.phymed.2004.03.005Scopus ID
2-s2.0-10844275745 (requires institutional sign-in at Scopus site) 81 CitationsAbstract
The fixed valerian-hops extract combination Ze91019 is used as a sleep aid. Although its exact mechanism of action is not well understood, earlier studies indicate that the CNS effect of valerian might occur through interaction with the GABA, melatonin and/or the adenosine systems in the brain. The use of hops in sleep remedies, however, is mainly based on traditional use and scarce scientific information. In this report, the binding of Ze91019, and the component valerian and hops extracts within, was tested on 14 subtypes of five classes of central receptors (dopamine, serotonin, melatonin, MCH and neuropeptide-Y). Binding affinities could be demonstrated at some of the screened melatonin (ML1 and ML2) and serotonin (5-HT4e, 5-HT6 and 5-HT7) receptor subtypes.
Author List
Abourashed EA, Koetter U, Brattström AAuthor
Ehab A. Abourashed PhD Professor in the School of Pharmacy Administration department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AnimalsBinding, Competitive
Chickens
Cricetinae
Drug Combinations
Humans
Humulus
Hypnotics and Sedatives
In Vitro Techniques
Logistic Models
Plant Extracts
Receptors, Cell Surface
Receptors, Dopamine
Receptors, Melatonin
Receptors, Neuropeptide Y
Receptors, Pituitary Hormone
Receptors, Serotonin
Valerian