Microbial transformation of kawain and methysticin. Chem Pharm Bull (Tokyo) 2000 Dec;48(12):1996-8
Date
01/06/2001Pubmed ID
11145158DOI
10.1248/cpb.48.1996Scopus ID
2-s2.0-0034536068 (requires institutional sign-in at Scopus site) 25 CitationsAbstract
The styryl alpha-pyrones, d-kawain (1) and d-methysticin (2) are two of the major kavalactone constituents of the anxiolvtic herb Piper methysticum, commonly known as kava. The use of fungal models to mimic the mammalian metabolism of 1 resulted in the production of 4'-hydroxykawain (1a) from the culture broth of Cunninghamella elegans (ATCC 9245), the same metabolite identified in rat urine. The fungus Torulopsis petrophilum (ATCC 20225) biotransformed 2 to 3'-hydroxy-4'-methoxykawain (2c) which is analogous, but not identical, to a known rat metabolite of methysticin.
Author List
Abourashed EA, Khan IAAuthor
Ehab A. Abourashed PhD Professor in the School of Pharmacy Administration department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AnimalsAnti-Anxiety Agents
Biotransformation
Cunninghamella
Neuroprotective Agents
Pyrans
Pyrones
Rats