Synthesis of Bisindole Alkaloids from the Apocynaceae Which Contain a Macroline or Sarpagine Unit: A Review. Molecules 2016 Nov 14;21(11)
Date
11/18/2016Pubmed ID
27854259Pubmed Central ID
PMC5214337DOI
10.3390/molecules21111525Scopus ID
2-s2.0-84997638270 (requires institutional sign-in at Scopus site) 48 CitationsAbstract
Bisindole natural products consist of two monomeric indole alkaloid units as their obligate constituents. Bisindoles are more potent with respect to their biological activity than their corresponding monomeric units. In addition, the synthesis of bisindoles are far more challenging than the synthesis of monomeric indole alkaloids. Herein is reviewed the enantiospecific total and partial synthesis of bisindole alkaloids isolated primarily from the Alstonia genus of the Apocynaceae family. The monomeric units belong to the sarpagine, ajmaline, macroline, vobasine, and pleiocarpamine series. An up-to-date discussion of their isolation, characterization, biological activity as well as approaches to their partial and total synthesis by means of both synthetic and biosynthetic strategies are presented.
Author List
Rahman MT, Tiruveedhula VV, Cook JMAuthor
James M. Cook PhD University Distinguished Professor in the Chemistry and Biochemistry department at University of Wisconsin - MilwaukeeMESH terms used to index this publication - Major topics in bold
Antineoplastic Agents, PhytogenicApocynaceae
Indole Alkaloids
Molecular Structure
Plant Extracts
Stereoisomerism
Vinblastine
Vincristine