Faculty Collaboration Database

A strategy for quantitative spectral imaging of tissue absorption and scattering using light emitting diodes and photodiodes. Opt Express 2009 Feb 02;17(3):1372-84

Date

02/04/2009

Pubmed ID

19188966

DOI

10.1364/oe.17.001372

Scopus ID

2-s2.0-59749102493 (requires institutional sign-in at Scopus site)   34 Citations

Abstract

A diffuse reflectance spectroscopy system was modified as a step towards miniaturization and spectral imaging of tissue absorption and scattering. The modified system uses a tunable source and an optical fiber for illumination and a photodiode in contact with tissue for detection. Compared to the previous system, it is smaller, less costly, and has comparable performance in extracting optical properties in tissue phantoms. Wavelength reduction simulations show the feasibility of replacing the source with LEDs to further decrease system size and cost. Simulated crosstalk analysis indicates that this evolving system can be multiplexed for spectral imaging in the future.

Author List

Lo JY, Yu B, Fu HL, Bender JE, Palmer GM, Kuech TF, Ramanujam N

Author

Bing Yu PH.D. Assistant Professor of Biomedical Engineering in the Biomedical Engineering department at Marquette University

MESH terms used to index this publication - Major topics in bold

Absorption
Computer Simulation
Hemoglobins
Humans
Light
Monte Carlo Method
Optics and Photonics
Phantoms, Imaging
Scattering, Radiation
Spectrum Analysis