Faculty Collaboration Database

Reduced electrogenic sodium-potassium pump in arterioles during renovascular hypertension. Hypertension 1987 Jun;9(6 Pt 2):III86-90

Date

06/01/1987

Pubmed ID

2439454

DOI

10.1161/01.hyp.9.6_pt_2.iii86

Scopus ID

2-s2.0-0023259281 (requires institutional sign-in at Scopus site)   4 Citations

Abstract

The goal of this study was to assess the role of the electrogenic Na+-K+ pump in controlling active tone in cremasteric arterioles of normotensive hamsters and hamsters with bilateral (two-kidney, two figure-8) Grollman hypertension. Arterioles of both groups exhibited a large transient dilation when the Na+-K+ pump was stimulated by superfusing the cremaster muscle with physiological salt solution containing 15 mM K+ after 20 minutes of 0 mM K+ superfusion. Arteriolar dilation in response to 15 mM K+ was significantly smaller in the hypertensive animals than in sham-operated controls. Ouabain (10(-5) M and 10(-3) M) inhibited arteriolar dilation in response to 15 mM K+ in both groups of animals. Resting diameters, total active tone (assessed by application of 10(-4) M adenosine), and arteriolar responses to inhibition of the Na+-K+ pump by superfusion with 0 mM K+ or ouabain were not significantly different in normotensive and hypertensive animals. These data indicate that an electrogenic Na+-K+ pump can regulate active tone in cremasteric arterioles, and that the maximum response of this pump to stimulation with 15 mM K+ is reduced in arterioles of hamsters with two-kidney Grollman hypertension.

Author List

Lombard JH, Joyner WL, Stekiel WJ

MESH terms used to index this publication - Major topics in bold

Adenosine
Animals
Arteries
Arterioles
Cricetinae
Electrophysiology
Hypertension, Renovascular
Ion Channels
Male
Mesocricetus
Osmolar Concentration
Ouabain
Perfusion
Potassium
Rest
Sodium
Tetrodotoxin