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Classification of Acute Pancreatitis in the Pediatric Population: Clinical Report From the NASPGHAN Pancreas Committee. J Pediatr Gastroenterol Nutr 2017 Jun;64(6):984-990

Date

03/24/2017

Pubmed ID

28333771

DOI

10.1097/MPG.0000000000001583

Scopus ID

2-s2.0-85015868731 (requires institutional sign-in at Scopus site)   141 Citations

Abstract

INTRODUCTION: Acute pancreatitis (AP) is an emerging problem in pediatrics, with most cases resolving spontaneously. Approximately 10% to 30%, however, are believed to develop "severe acute pancreatitis" (SAP).

METHODS: This consensus statement on the classification of AP in pediatrics was developed through a working group that performed an evidence-based search for classification of AP in adult pancreatitis, definitions and criteria of systemic inflammatory response syndrome, and organ failure in pediatrics.

RESULTS AND DISCUSSION: Severity in pediatric AP is classified as mild, moderately severe, or severe. Mild AP is defined by AP without organ failure, local or systemic complications, and usually resolves in the first week. Moderately SAP is defined by the presence of transient organ failure that resolves in no >48 hours, or local complications or exacerbation of co-morbid disease. SAP is defined by persistent organ failure that lasts <48 hours. The presence of systemic inflammatory response syndrome is associated with increased risk for persistent organ dysfunction. Criteria to define organ failure must be pediatric- and age-based.

CONCLUSIONS: Classifying AP in pediatrics in a uniform fashion will help define outcomes and encourage the development of future studies in the field of pediatric pancreatitis.

Author List

Abu-El-Haija M, Kumar S, Szabo F, Werlin S, Conwell D, Banks P, Morinville VD, NASPGHAN Pancreas Committee

Author

Steven L. Werlin MD Emeritus Professor in the Pediatrics department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Acute Disease
Child
Humans
Multiple Organ Failure
Pancreatitis
Pediatrics
Severity of Illness Index
Systemic Inflammatory Response Syndrome