Medical College of Wisconsin
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Abnormal analyte preeclampsia: do the second-trimester maternal serum analytes help differentiate preeclampsia subtypes? J Perinatol 2013 Oct;33(10):754-8

Date

05/25/2013

Pubmed ID

23702620

Pubmed Central ID

PMC3760989

DOI

10.1038/jp.2013.55

Scopus ID

2-s2.0-84885021251 (requires institutional sign-in at Scopus site)   4 Citations

Abstract

OBJECTIVE: To determine if serum screen analytes identify preeclamptic patients at risk for small-for-gestational age newborns, maternal laboratory abnormalities and preterm delivery (<37 weeks gestation).

STUDY DESIGN: Using a retrospective cohort of 102 preeclamptic patients, associations between serum screen analytes and newborn birth-weight percentile, gestational age (GA) at delivery and maternal pre-delivery laboratory abnormalities were evaluated using correlation coefficients and local polynomial regression.

RESULT: Inhibin-A and maternal serum alpha fetoprotein were inversely correlated with newborn birth-weight percentile (-0.27, P=0.006; -0.35, P=0.00004) and delivery GA (r=-0.42, P<0.0001; r=-0.26, P=0.008) and positively correlated with pre-delivery aspartate aminotransferase (r=0.22, P=0.03; r=0.21, P=0.04) and lactate dehydrogenase (r=0.33, P=0.0007; r=0.29, P=0.004). A positive correlation was noted between both second-trimester beta human chorionic gonadotropin and estriol and maternal pre-delivery creatinine (0.28, P=0.004; 0.4, P<0.0001, respectively). Hundred percent of patients with ≥ 2 abnormal analytes delivered before 37 weeks gestation.

CONCLUSION: Preeclamptic patients with abnormal serum screen analytes are more likely to have small-for-gestational age newborns, deliver preterm and have pre-delivery laboratory abnormalities.

Author List

Critchfield AS, Paulus JK, Farez R, Urato AC

Author

Rahmouna Leila Farez MD Associate Professor in the Obstetrics and Gynecology department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Adult
Birth Weight
Chorionic Gonadotropin, beta Subunit, Human
Estriol
Female
Gestational Age
HELLP Syndrome
Humans
Infant, Newborn
Infant, Small for Gestational Age
Inhibins
Maternal Serum Screening Tests
Pre-Eclampsia
Pregnancy
Pregnancy Proteins
Pregnancy Trimester, Second
Pregnancy-Associated Plasma Protein-A
Premature Birth
Retrospective Studies
alpha-Fetoproteins