SerpinC1/Antithrombin III in kidney-related diseases. Clin Sci (Lond) 2017 May 01;131(9):823-831
Date
04/21/2017Pubmed ID
28424376Pubmed Central ID
PMC5396475DOI
10.1042/CS20160669Scopus ID
2-s2.0-85015719921 (requires institutional sign-in at Scopus site) 50 CitationsAbstract
The gene SerpinC1 encodes a serine protease inhibitor named antithrombin III (ATIII). This protease demonstrates both anticoagulant and anti-inflammatory action. ATIII is the most important coagulation factor inhibitor, and even minor changes in ATIII can significantly alter the risk of thromboembolism. ATIII can also suppress inflammation via a coagulation-dependent or -independent effect. Moreover, apart from ATIII deficiency, ATIII and its gene SerpinC1 may also be related to many diseases (e.g. hypertension, kidney diseases). The present review summarizes how ATIII affects the progress of kidney disease and its mechanism. Further studies are required to investigate how ATIII affects renal function and the treatment.
Author List
Lu Z, Wang F, Liang MMESH terms used to index this publication - Major topics in bold
Antithrombin IIIAntithrombin III Deficiency
Blood Coagulation
Humans
Inflammation
Kidney Diseases
Models, Biological
Risk Factors
Signal Transduction
Thromboembolism
