Zebrafish Models of Retinal Disease. Annu Rev Vis Sci 2015 Nov 24;1:125-153
Date
11/24/2015Pubmed ID
28532376DOI
10.1146/annurev-vision-082114-035717Abstract
Visual defects affect a large proportion of humanity, have a significant negative impact on quality of life, and cause significant economic burden. The wide variety of visual disorders and the large number of gene mutations responsible require a flexible animal model system to carry out research for possible causes and cures for the blinding conditions. With eyes similar to humans in structure and function, zebrafish are an important vertebrate model organism that is being used to study genetic and environmental eye diseases, including myopia, glaucoma, retinitis pigmentosa, ciliopathies, albinism, and diabetes. This review details the use of zebrafish in modeling human ocular diseases.
Author List
Link BA, Collery RFAuthors
Ross F. Collery PhD Associate Professor in the Ophthalmology department at Medical College of WisconsinBrian A. Link PhD Professor in the Cell Biology Neurobiology and Anatomy department at Medical College of Wisconsin
