The Goldilocks model of immune symbiosis with Mycobacteria and Candida colonizers. Cytokine 2017 Sep;97:49-65
Date
06/02/2017Pubmed ID
28570933Pubmed Central ID
PMC5765749DOI
10.1016/j.cyto.2017.05.015Scopus ID
2-s2.0-85019740661 (requires institutional sign-in at Scopus site) 17 CitationsAbstract
Mycobacteria and Candida species include significant human pathogens that can cause localized or disseminated infections. Although these organisms may appear to have little in common, several shared pathways of immune recognition and response are important for both control and infection-related pathology. In this article, we compare and contrast the innate and adaptive components of the immune system that pertain to these infections in humans and animal models. We also explore a relatively new concept in the mycobacterial field: biological commensalism. Similar to the well-established model of Candida infection, Mycobacteria species colonize their human hosts in equilibrium with the immune response. Perturbations in the immune response permit the progression to pathologic disease at the expense of the host. Understanding the immune factors required to maintain commensalism may aid with the development of diagnostic and treatment strategies for both categories of pathogens.
Author List
Robinson RT, Huppler ARAuthor
Anna Huppler MD Associate Professor in the Pediatrics department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
Adaptive ImmunityAnimals
Candida
Candidiasis
Disease Models, Animal
Humans
Immunity, Innate
Mycobacterium
Symbiosis
Tuberculosis
