Effect of Comonomers on Physical Properties and Cell Attachment to Silica-Methacrylate/Acrylate Hybrids for Bone Substitution. Macromol Rapid Commun 2017 Aug;38(15)
Date
06/01/2017Pubmed ID
28564490DOI
10.1002/marc.201700168Scopus ID
2-s2.0-85026777022 (requires institutional sign-in at Scopus site) 9 CitationsAbstract
Hybrids with a silica network covalently bonded to a polymer are promising materials for bone repair. Previous work on synthesizing methyl methacrylate (MMA) based copolymers by reversible addition-fragmentation chain transfer (RAFT) polymerization gives high tailorability of mechanical properties since sophisticated polymer structures can be designed. However, more flexible hybrids would be beneficial. Here, n-butyl methacrylate (BMA) and methyl acrylate (MA) based hybrids are produced. Unlike MMA, BMA and MA hybrids do not show plastic deformation, and BMA hybrid has strain to failure of 33%. Although the new hybrids are more flexible, preosteoblast cells do not adhere on their surfaces, due to higher hydrophobicity and lower stiffness. Comonomer choice is crucial for bone regenerative hybrids.
Author List
Chung JJ, Sum BST, Li S, Stevens MM, Georgiou TK, Jones JRAuthor
Test W. User test user title in the Anesthesiology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AcrylatesBone Substitutes
Methacrylates
Osteoblasts
Polymerization
Polymers
Silicon Dioxide