BK virus nephritis after renal transplantation. Clin J Am Soc Nephrol 2008 Mar;3 Suppl 2(Suppl 2):S68-75
Date
03/20/2008Pubmed ID
18309005Pubmed Central ID
PMC3152275DOI
10.2215/CJN.02770707Scopus ID
2-s2.0-41749121023 (requires institutional sign-in at Scopus site) 123 CitationsAbstract
BK virus nephritis is an increasing problem and is posing a threat to improving renal transplant graft survival. The pathogenesis of this condition remains to be investigated. Higher prevalence of BK virus infection in recent years has been correlated with declining acute rejection rates and the use of potent immunosuppressive agents. Patients with this infection usually have asymptomatic viremia and/or nephritis with or without worsening of renal function. The diagnosis of this disease is based on detecting the virus or its effects in urine, blood, and renal tissue. In the past, approximately 30 to 60% of patients with BK virus nephritis developed graft failure. In recent years, the combination of early detection, prompt diagnosis, and therapies including preventive measures have resulted in better outcomes.
Author List
Dall A, Hariharan SAuthor
Aaron Dall MD Interim Chief, Associate Professor in the Medicine department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
BK VirusHumans
Kidney Transplantation
Nephritis
Polyomavirus Infections
Postoperative Complications
Risk Factors
Tumor Virus Infections
