Medical College of Wisconsin
CTSICores SearchResearch InformaticsREDCap

Functional connectivity density mapping: comparing multiband and conventional EPI protocols. Brain Imaging Behav 2018 Jun;12(3):848-859



Pubmed ID




Scopus ID

2-s2.0-85021816914 (requires institutional sign-in at Scopus site)   13 Citations


Functional connectivity density mapping (FCDM) is a newly developed data-driven technique that quantifies the number of local and global functional connections for each voxel in the brain. In this study, we evaluated reproducibility, sensitivity, and specificity of both local functional connectivity density (lFCD) and global functional connectivity density (gFCD). We compared these metrics using the human connectome project (HCP) compatible high-resolution (2 mm isotropic, TR = 0.8 s) multiband (MB), and more typical, lower resolution (3.5 mm isotropic, TR = 2.0 s) single-band (SB) resting state functional MRI (rs-fMRI) acquisitions. Furthermore, in order to be more clinically feasible, only rs-fMRI scans that lasted seven minutes were tested. Subjects were scanned twice within a two-week span. We found sensitivity and specificity increased and reproducibility either increased or did not change for the MB compared to the SB acquisitions. The MB scans also showed improved gray matter/white matter contrast compared to the SB scans. The lFCD and gFCD patterns were similar across MB and SB scans and confined predominantly to gray matter. We also observed a strong spatial correlation of FCD between MB and SB scans indicating the two acquisitions provide similar information. These findings indicate high-resolution MB acquisitions improve the quality of FCD data, and seven minute rs-fMRI scan can provide robust FCD measurements.

Author List

Cohen AD, Tomasi D, Shokri-Kojori E, Nencka AS, Wang Y


Andrew S. Nencka PhD Director, Associate Professor in the Radiology department at Medical College of Wisconsin
Yang Wang MD Professor in the Radiology department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Gray Matter
Magnetic Resonance Imaging
Middle Aged
Neural Pathways
Reproducibility of Results
White Matter
Young Adult