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Sucrose Non-Fermenting Related Kinase Expression in Ovarian Cancer and Correlation with Clinical Features. Cancer Invest 2017 Aug 09;35(7):456-462

Date

07/20/2017

Pubmed ID

28722495

Pubmed Central ID

PMC6167932

DOI

10.1080/07357907.2017.1337781

Scopus ID

2-s2.0-85025168444

Abstract

Sucrose non-fermenting related kinase (SNRK) is a serine/threonine kinase known to regulate cellular metabolism and adipocyte inflammation. Since alterations in adipocyte metabolism play a role in ovarian cancer metastasis, we investigated the expression of SNRK in benign and malignant human ovarian tissue using immunohistochemistry and qPCR. The number of SNRK positive (+) nuclei is increased in malignant tissue compared to benign tissue (21.03% versus 14.90%, p < .0431). The most strongly stained malignant SNRK+ nuclei were stage 1 compared to stage 2-4 disease. Differential expression of SNRK in early versus late stage disease suggests specific roles for SNRK in ovarian cancer metastasis.

Author List

Hopp EE, Cossette SM, Kumar SN, Eastwood D, Ramchandran R, Bishop E

Authors

Erin Bishop MD Assistant Professor in the Obstetrics and Gynecology department at Medical College of Wisconsin
Elizabeth E. Hopp MD Assistant Professor in the Obstetrics and Gynecology department at Medical College of Wisconsin
Suresh Kumar PhD Associate Professor in the Pathology department at Medical College of Wisconsin
Ramani Ramchandran PhD Professor in the Pediatrics department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Adult
Aged
Aged, 80 and over
Biomarkers, Tumor
Female
Gene Expression Regulation, Enzymologic
Gene Expression Regulation, Neoplastic
Humans
Immunohistochemistry
Middle Aged
Neoplasm Grading
Neoplasm Staging
Neoplasms, Glandular and Epithelial
Ovarian Neoplasms
Protein-Serine-Threonine Kinases
RNA, Messenger
Real-Time Polymerase Chain Reaction
Reverse Transcriptase Polymerase Chain Reaction
jenkins-FCD Prod-482 91ad8a360b6da540234915ea01ff80e38bfdb40a