Sucrose Non-Fermenting Related Kinase Expression in Ovarian Cancer and Correlation with Clinical Features. Cancer Invest 2017 Aug 09;35(7):456-462
Date
07/20/2017Pubmed ID
28722495Pubmed Central ID
PMC6167932DOI
10.1080/07357907.2017.1337781Scopus ID
2-s2.0-85025168444 (requires institutional sign-in at Scopus site) 4 CitationsAbstract
Sucrose non-fermenting related kinase (SNRK) is a serine/threonine kinase known to regulate cellular metabolism and adipocyte inflammation. Since alterations in adipocyte metabolism play a role in ovarian cancer metastasis, we investigated the expression of SNRK in benign and malignant human ovarian tissue using immunohistochemistry and qPCR. The number of SNRK positive (+) nuclei is increased in malignant tissue compared to benign tissue (21.03% versus 14.90%, p < .0431). The most strongly stained malignant SNRK+ nuclei were stage 1 compared to stage 2-4 disease. Differential expression of SNRK in early versus late stage disease suggests specific roles for SNRK in ovarian cancer metastasis.
Author List
Hopp EE, Cossette SM, Kumar SN, Eastwood D, Ramchandran R, Bishop EAuthors
Erin Bishop MD Associate Professor in the Obstetrics and Gynecology department at Medical College of WisconsinElizabeth E. Hopp MD Assistant Professor in the Obstetrics and Gynecology department at Medical College of Wisconsin
Suresh Kumar PhD Associate Professor in the Pathology department at Medical College of Wisconsin
Ramani Ramchandran PhD Professor in the Pediatrics department at Medical College of Wisconsin
MESH terms used to index this publication - Major topics in bold
AdultAged
Aged, 80 and over
Biomarkers, Tumor
Female
Gene Expression Regulation, Enzymologic
Gene Expression Regulation, Neoplastic
Humans
Immunohistochemistry
Middle Aged
Neoplasm Grading
Neoplasm Staging
Neoplasms, Glandular and Epithelial
Ovarian Neoplasms
RNA, Messenger
Real-Time Polymerase Chain Reaction
Reverse Transcriptase Polymerase Chain Reaction