Reduced environmental exposure to aerosolized ribavirin using a simple containment system. Pediatr Infect Dis J 1991 Mar;10(3):217-21
Date
03/01/1991Pubmed ID
2041670DOI
10.1097/00006454-199103000-00010Scopus ID
2-s2.0-0025892068 (requires institutional sign-in at Scopus site) 10 CitationsAbstract
To minimize the exposure of health care workers to aerosolized ribavirin, we designed a double tent containment system with circulating mist and suction applied between the tents and we evaluated the ability of this system to contain and evacuate aerosolized ribavirin. While the drug was administered with this system at three institutions, three air sampling pumps at different locations in the room and one worn by the investigator (personal breathing zone) collected air samples onto filters for assay of ambient ribavirin. Ribavirin determinations were made by high performance liquid chromatography. A 5- to greater than 20-fold decrease in ambient ribavirin concentrations was observed with the containment system compared with those detected with a single oxyhood in use. The personal breathing zone concentration was 566.0 micrograms/m3 with the oxyhood alone and fell to a mean concentration of 43.81 +/- 33.40 micrograms/m3 with the containment system. Though the risk to exposed health care workers is unknown, this system offers a simple way to decrease significantly occupational exposure to ribavirin.
Author List
Torres A Jr, Krilov LR, Jacobson JM, Kelly KJ, Havens PLAuthor
Peter Havens MD Emeritus Professor in the Pediatrics department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
Administration, InhalationAerosols
Air Pollutants, Occupational
Atmosphere Exposure Chambers
Equipment Design
Humans
Occupational Exposure
Ribavirin
