Clinical Phenotypes of Fontan Failure: Implications for Management. Congenit Heart Dis 2016 Jul;11(4):296-308
Date
05/27/2016Pubmed ID
27226033DOI
10.1111/chd.12368Scopus ID
2-s2.0-84981737316 (requires institutional sign-in at Scopus site) 111 CitationsAbstract
Fontan failure has been variably and inconsistently described in the literature, leading to challenges in comparing studies and evaluating treatments. Development of a conceptual framework to describe clinical phenotypes will aid in consistent terminology in the literature. In the heart failure literature, several key concepts have been described-"heart failure" is a clinical syndrome of various etiologies, with phenotype-specific response to therapies. As the congenital heart disease community struggles to grapple with "Fontan failure," these concepts come to light. Fontan failure in the context of four clinical phenotypes, including evaluation, potential management strategies, and future directions is discussed.
Author List
Book WM, Gerardin J, Saraf A, Marie Valente A, Rodriguez F 3rdAuthor
Jennifer Gerardin MD Associate Professor in the Pediatrics department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
Fontan ProcedureHeart Defects, Congenital
Hemodynamics
Humans
Lymphatic System
Phenotype
Postoperative Complications
Regional Blood Flow
Risk Factors
Stroke Volume
Treatment Failure
Ventricular Pressure
